Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Many mutations disappear from the population because they impair protein function and/or
stability. Thus, amino acid positions that are essential for proper function evolve more slowly …

The ConSurf web‐sever for the analysis of proteins, RNA, and DNA provides a quick and
accurate estimate of the per‐site evolutionary rate among homologues. The analysis reveals …

Abstract IQ-TREE (http://www. iqtree. org, last accessed February 6, 2020) is a user-friendly
and widely used software package for phylogenetic inference using maximum likelihood …

AlphaFold2 has revolutionized protein structure prediction by leveraging sequence
information to rapidly model protein folds with atomic‐level accuracy. Nevertheless, previous …

The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in
DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to …

Determining the most suitable model for phylogeny reconstruction constitutes a fundamental
step in numerous evolutionary studies. Over the years, various criteria for model selection …

PredictProtein is a meta-service for sequence analysis that has been predicting structural
and functional features of proteins since 1992. Queried with a protein sequence it returns …

The mustard family (Brassicaceae) is a scientifically and economically important family,
containing the model plant Arabidopsis thaliana and numerous crop species that feed …

It is informative to detect highly conserved positions in proteins and nucleic acid
sequence/structure since they are often indicative of structural and/or functional importance …