[HTML][HTML] scRepertoire: An R-based toolkit for single-cell immune receptor analysis

N Borcherding, NL Bormann, G Kraus - F1000Research, 2020 - ncbi.nlm.nih.gov
Single-cell sequencing is an emerging technology in the field of immunology and oncology
that allows researchers to couple RNA quantification and other modalities, like immune cell …

Dendritic cells or macrophages? The microenvironment of human clear cell renal cell carcinoma imprints a mosaic myeloid subtype associated with patient survival

D Brech, AS Herbstritt, S Diederich, T Straub… - Cells, 2022 - mdpi.com
Since their initial description by Elie Metchnikoff, phagocytes have sparked interest in a
variety of biologic disciplines. These important cells perform central functions in tissue repair …

Understanding and targeting human cancer regulatory T cells to improve therapy

HR Kolb, N Borcherding, W Zhang - T Regulatory Cells in Human Health …, 2021 - Springer
Regulatory T cells (Tregs) are critical in maintaining immune homeostasis under various
pathophysiological conditions. A growing body of evidence demonstrates that Tregs play an …

[HTML][HTML] Single-cell transcriptomics: a novel precision medicine technique in nephrology

J Kim, J Park - The Korean Journal of Internal Medicine, 2021 - ncbi.nlm.nih.gov
Due to the complex structure and function of the kidneys, the mechanism of kidney disease
is unclear. In particular, transcriptomics approaches at the bulk level are unable to …

Single‐Cell and Transcriptome‐Based Immune Cell‐Related Prognostic Model in Clear Cell Renal Cell Carcinoma

G Wu, W Guo, S Zhu, G Fan - Journal of Oncology, 2023 - Wiley Online Library
Traditional studies mostly focus on the role of single gene in regulating clear cell renal cell
carcinoma (ccRCC), while it ignores the impact of tumour heterogeneity on disease …

Integrated analysis of single-cell and transcriptome based RNA-seq multilayer network and WGCNA for construction and validation of an immune cell-related …

G Wu, M Liu, W Yang, S Zhu, W Guo, G Huang, L Xie… - bioRxiv, 2021 - biorxiv.org
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer (RCC).
The increasing incidence and poor prognosis of ccRCC after tumour metastasis makes the …

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

G Mijnheer, L Lutter, M Mokry, M van der Wal… - bioRxiv, 2020 - biorxiv.org
Treg are critical regulators of immune homeostasis, and increasing evidence demonstrates
that environment-driven Treg differentiation into effector (e) Treg is crucial for optimal …