The journey of embryonic development starts at oocyte fertilization, which triggers a complex
cascade of events and cellular pathways that guide early embryogenesis. Recent …

Abstract CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown
to play a role in many cellular activities including cell cycle progression, apoptosis and …

PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients. Several of those
patients exhibit intrinsic/acquired resistance mechanisms that limit efficacy of PARPi …

Aberrant epigenetic reprogramming is a major factor of developmental failure of cloned
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …

If no fertilization occurs at an appropriate time after ovulation, oocyte quality deteriorates
rapidly as a process called postovulatory aging. Because the postovulatory aging of oocytes …

Synchronization of ovary development is the premise for realizing large-scale seed breeding
of small-and medium-sized shrimps. To explore the genetic mechanism that determines …

Abstract Cyclin-dependent kinases (CDKs), a family of cell cycle-related serine/threonine
kinases, participate in various biological processes, and play crucial roles in the innate …

While few studies have revealed the biological properties of brassicasterol, a phytosterol,
against some biological and molecular targets, it is believed that there are still many …

In mammals, E2 factor (E2F) acts as a cell cycle regulator. E2F transcription factor 4 (E2F4)
is a member of the E2F family of transcription factors and usually represents predominant …

The role of cumulus cells (CCs) in the acquisition of oocyte developmental competence is
not yet fully understood. In a previous study, we matured cumulus-denuded fully-grown …