CB1 and CB2 receptor pharmacology
AC Howlett, ME Abood - Advances in Pharmacology, 2017 - Elsevier
The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …
Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …
has been one of the most significant biochemical and pharmacological advancements to …
Cannabis: a toxin-producing plant with potential therapeutic uses
For thousands of years, Cannabis sativa has been utilized as a medicine and for
recreational and spiritual purposes. Phytocannabinoids are a family of compounds that are …
recreational and spiritual purposes. Phytocannabinoids are a family of compounds that are …
The cannabinoid receptor
AC Howlett, DM Evans, DB Houston - Marijuana/cannabinoids, 2019 - taylorfrancis.com
In the case of the cannabinoid receptor, the lack of potent antagonists has been a limiting
factor in defining cannabinoid receptor-mediated responses. Several lines of evidence …
factor in defining cannabinoid receptor-mediated responses. Several lines of evidence …
Cannabinoid receptors and pain
RG Pertwee - Progress in neurobiology, 2001 - Elsevier
Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both
coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and …
coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and …
Cannabinoid signalling
DG Demuth, A Molleman - Life sciences, 2006 - Elsevier
After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …
Cannabinoid receptor signaling
AC Howlett - Cannabinoids, 2005 - Springer
The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …
The endocannabinoid system: physiology and pharmacology
F Rodríguez de Fonseca, I Del Arco… - Alcohol and …, 2005 - academic.oup.com
The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …
early in evolution and which has important regulatory functions throughout the body in all …
Distribution of the endocannabinoid system in the central nervous system
SSJ Hu, K Mackie - Endocannabinoids, 2015 - Springer
The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …
The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
V Di Marzo - Pharmacological research, 2009 - Elsevier
The endocannabinoid signalling system includes:(1) at least two G-protein-coupled
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …