[HTML][HTML] Revealing nucleic acid mutations using Förster resonance energy transfer-based probes

NPL Junager, J Kongsted, K Astakhova - Sensors, 2016 - mdpi.com
Nucleic acid mutations are of tremendous importance in modern clinical work, biotechnology
and in fundamental studies of nucleic acids. Therefore, rapid, cost-effective and reliable …

Unveiling potential inhibitors targeting the nucleocapsid protein of SARS-CoV-2: Structural insights into their binding sites

S Kumari, H Mistry, SC Bihani, SP Mukherjee… - International Journal of …, 2024 - Elsevier
The Nucleocapsid (N) protein of SARS-CoV-2 plays a crucial role in viral replication and
pathogenesis, making it an attractive target for developing antiviral therapeutics. In this …

[HTML][HTML] Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ

S Sahu, F Philip, S Scarlata - Journal of Biological Chemistry, 2014 - ASBMB
C3PO plays a key role in promoting RNA-induced gene silencing. C3PO consists of two
subunits of the endonuclease translin-associated factor X (TRAX) and six subunits of the …

Molecular evolution of translin superfamily proteins within the genomes of eubacteria, archaea and eukaryotes

GD Gupta, A Kale, V Kumar - Journal of molecular evolution, 2012 - Springer
Translin and its interacting partner protein, TRAX, are members of the translin superfamily.
These proteins are involved in mRNA regulation and in promoting RISC activity by removing …

Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO

EA Parizotto, ED Lowe, JS Parker - Nature structural & molecular …, 2013 - nature.com
Oligomeric complexes of Trax and Translin proteins, known as C3POs, participate in several
eukaryotic nucleic acid metabolism pathways, including RNA interference and tRNA …

Characterization of a plant (rice) translin and its comparative analysis with human translin

RK Chittela, GD Gupta, A Ballal - Planta, 2014 - Springer
Main conclusion For the first time, a plant (rice) translin was characterized. The rice translin
protein, which was octameric in native state, bound efficiently to single-stranded DNA and …

C-terminal residues of rice translin are essential for octamer formation and nucleic acid binding

A Gupta, A Nair, A Ballal, RK Chittela - Plant Physiology and Biochemistry, 2017 - Elsevier
Translin is a DNA/RNA binding protein involved in DNA repair and RNA metabolism.
Previously, we had shown that rice translin (221 amino acids) exhibits biochemical activities …

A novel open-barrel structure of octameric translin reveals a potential RNA entryway

E Eliahoo, A Marx, H Manor, A Alian - Journal of Molecular Biology, 2015 - Elsevier
The single-stranded DNA (ssDNA)/RNA binding protein translin was suggested to be
involved in chromosomal translocations, telomere metabolism, and mRNA transport and …

Novel Regulation of the Transcription Factor ZHX2 by Nα-Modification

MM Conner - 2023 - search.proquest.com
Protein N-terminal (Nα) modifications, occurring both co-and post-translationally on the α-
amino group at the N-terminus of proteins, regulate many aspects of protein biochemistry …

Recombination hot-spots and defense players–maintenance of genomic integrity

RP Kamdar, BJ Rao - New Research Directions in DNA Repair, 2013 - books.google.com
Internal factors and external agents are a source of constant genomic stress in living organ‐-
isms leading to instability in the form of chromosomal deletions, duplications and transloca …