Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using Cryo-EM
Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …
present different challenges for structure determination. They are biologically important for …
[PDF][PDF] Approaches to altering particle distributions in cryo-electron microscopy sample preparation
Cryo-electron microscopy (cryo-EM) can now be used to determine high-resolution structural
information on a diverse range of biological specimens. Recent advances have been driven …
information on a diverse range of biological specimens. Recent advances have been driven …
Automatic local resolution-based sharpening of cryo-EM maps
Motivation Recent technological advances and computational developments have allowed
the reconstruction of Cryo-Electron Microscopy (cryo-EM) maps at near-atomic resolution …
the reconstruction of Cryo-Electron Microscopy (cryo-EM) maps at near-atomic resolution …
Collection, pre-processing and on-the-fly analysis of data for high-resolution, single-particle cryo-electron microscopy
The dramatic growth in the use of cryo-electron microscopy (cryo-EM) to generate high-
resolution structures of macromolecular complexes has changed the landscape of structural …
resolution structures of macromolecular complexes has changed the landscape of structural …
The cytochrome bc1 complex as an antipathogenic target
N Fisher, B Meunier, GA Biagini - Febs Letters, 2020 - Wiley Online Library
The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of
many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi …
many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi …
[HTML][HTML] Tuberculosis: Past, present and future of the treatment and drug discovery research
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium
tuberculosis. Despite decades of research driving advancements in drug development and …
tuberculosis. Despite decades of research driving advancements in drug development and …
Mitonuclear coevolution, but not nuclear compensation, drives evolution of OXPHOS complexes in bivalves
In Metazoa, four out of five complexes involved in oxidative phosphorylation (OXPHOS) are
formed by subunits encoded by both the mitochondrial (mtDNA) and nuclear (nuDNA) …
formed by subunits encoded by both the mitochondrial (mtDNA) and nuclear (nuDNA) …
Potent tetrahydroquinolone eliminates apicomplexan parasites
MJ McPhillie, Y Zhou, MR Hickman… - Frontiers in cellular …, 2020 - frontiersin.org
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New,
improved therapies are needed. Herein, we create a next generation anti-apicomplexan …
improved therapies are needed. Herein, we create a next generation anti-apicomplexan …
Targeting the Ubiquinol-Reduction (Qi) Site of the Mitochondrial Cytochrome bc1 Complex for the Development of Next Generation Quinolone Antimalarials
K Amporndanai, N Pinthong, PM O'Neill, WD Hong… - Biology, 2022 - mdpi.com
Simple Summary Malaria is a life-threatening disease which infects millions of people a year
via mosquito bites, particularly in developing countries. Although many malaria drugs are …
via mosquito bites, particularly in developing countries. Although many malaria drugs are …
Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy
Cytochrome (cyt) bc 1, bcc and b 6 f complexes, collectively referred to as cyt bc complexes,
are homologous isoprenoid quinol oxidising enzymes present in diverse phylogenetic …
are homologous isoprenoid quinol oxidising enzymes present in diverse phylogenetic …