The increasing extension in life expectancy of human beings in developed countries is
accompanied by a progressively greater rate of degenerative diseases associated with …

Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell
dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have …

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic
with potential antiaging and antidiabetogenic properties. It is widely consumed as a …

In recent years, there is growing evidence that plant-foods polyphenols, due to their
biological properties, may be unique nutraceuticals and supplementary treatments for …

The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …

Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a
large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which
coordinates metabolic pathways and thus balances nutrient supply with energy demand …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Excessive misfolded proteins and/or dysfunctional mitochondria, which may cause energy
deficiency, have been implicated in the etiopathogenesis of Parkinson's disease (PD) …