A screening study for the development of simvastatin-doxorubicin liposomes, a co-formulation with future perspectives in colon cancer therapy
An increasing number of studies published so far have evidenced the benefits of Simvastatin
(SIM) and Doxorubicin (DOX) co-treatment in colorectal cancer. In view of this, the current …
(SIM) and Doxorubicin (DOX) co-treatment in colorectal cancer. In view of this, the current …
Simvastatin Reduces Doxorubicin-Induced Cardiotoxicity: Effects beyond Its Antioxidant Activity
M Pecoraro, S Marzocco, R Belvedere… - International Journal of …, 2023 - mdpi.com
This study aimed to evaluate if Simvastatin can reduce, and/or prevent, Doxorubicin (Doxo)-
induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then …
induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then …
Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism
CC Anderson, JO Marentette, KM Prutton… - Free Radical Biology …, 2021 - Elsevier
Down syndrome (DS) is the most common genetic cause of intellectual disability.
Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological …
Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological …
Simvastatin coadministration modulates the electrostatically driven incorporation of doxorubicin into model lipid and cell membranes
A Bartkowiak, E Nazaruk, E Gajda… - ACS Biomaterials …, 2022 - ACS Publications
Understanding the interactions between drugs and lipid membranes is a prerequisite for
finding the optimal way to deliver drugs into cells. Coadministration of statins and anticancer …
finding the optimal way to deliver drugs into cells. Coadministration of statins and anticancer …
A phase 1 study of simvastatin in combination with topotecan and cyclophosphamide in pediatric patients with relapsed and/or refractory solid and CNS tumors
T Cash, HC Jonus, M Tsvetkova… - Pediatric Blood & …, 2023 - Wiley Online Library
Abstract Background 3‐Hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase
inhibitors (statins) can inhibit tumor proliferation, angiogenesis, and restore apoptosis in …
inhibitors (statins) can inhibit tumor proliferation, angiogenesis, and restore apoptosis in …
Effect of Black Rice Bran 'Sembada Hitam'on T47D Breast Cancer Cells: Effect of Black rice bran on T47D
FC Conara, G Oktavya, YA Purwestri… - Journal of Tropical Life …, 2023 - jtrolis.ub.ac.id
Indonesians have a rich tradition of incorporating black rice into their diet as a functional
food due to its high antioxidant content. This research investigates the effects of the …
food due to its high antioxidant content. This research investigates the effects of the …