Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

Chromosomal aneuploidies are a defining feature of carcinomas, ie, tumors of epithelial
origin. Such aneuploidies result in tumor specific genomic copy number alterations. The …

Evidence has accumulated to demonstrate that the intestinal microbiota enhances
mammalian enteric virus infections. For example, we and others previously reported that …

Cellular tropism during persistent viral infection is commonly conferred by the interaction of a
viral surface protein with a host receptor complex. Norovirus, the leading global cause of …

The cellular origin of hepatocellular carcinomas (HCC) and the role of Notch1 signalling in
HCC initiation are controversial. Herein, we establish Notch1 as a regulator of HCC …

Here, we report that kinase-dead IKKα knockin mice develop spontaneous lung squamous
cell carcinomas (SCCs) associated with IKKα downregulation and marked pulmonary …

Deletion of tumor suppressor genes in stromal fibroblasts induces epithelial cancer
development, suggesting an important role of stroma in epithelial homoeostasis. However …

Epigenetic regulation of chromatin states is thought to control gene expression programs
during lineage specification. However, the roles of repressive histone modifications, such as …

Background Adipose-tissue stem cells (ASCs) are subject of intensive research since their
successful use in regenerative therapy. The drawback of ASCs is that they may serve as …

Circumstantial evidence suggests that colon carcinogenesis can ensue the transient
tetraploidization of (pre-) malignant cells. In line with this notion, the tumor suppressors APC …