Complement in the brain: contributions to neuroprotection, neuronal plasticity, and neuroinflammation

SS Bohlson, AJ Tenner - Annual Review of Immunology, 2023 - annualreviews.org
The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

[HTML][HTML] Neuroinflammation microenvironment sharpens seizure circuit

B Villasana-Salazar, A Vezzani - Neurobiology of Disease, 2023 - Elsevier
A large set of inflammatory molecules and their receptors are induced in epileptogenic foci
of patients with pharmacoresistant epilepsies of structural etiologies or with refractory status …

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

S De Schepper, JZ Ge, G Crowley, LSS Ferreira… - Nature …, 2023 - nature.com
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …

[HTML][HTML] Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease

DK Wilton, K Mastro, MD Heller, FW Gergits… - Nature medicine, 2023 - nature.com
Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy

HY Chung, J Wickel, N Hahn, N Mein… - Science …, 2023 - science.org
Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis
causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and …

Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents

FS Cho, ID Vainchtein, Y Voskobiynyk… - Science translational …, 2022 - science.org
Inflammatory processes induced by brain injury are important for recovery; however, when
uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory …

C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer's disease mouse model

ND Schartz, HY Liang, K Carvalho, SH Chu… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …

Microglia modulate general anesthesia through P2Y12 receptor

K Cao, L Qiu, X Lu, W Wu, Y Hu, Z Cui, C Jiang, Y Luo… - Current Biology, 2023 - cell.com
General anesthesia (GA) is an unconscious state produced by anesthetic drugs, which act
on neurons to cause overall suppression of neuronal activity in the brain. Recent studies …

Hidden behavioral fingerprints in epilepsy

T Gschwind, A Zeine, I Raikov, JE Markowitz, WF Gillis… - Neuron, 2023 - cell.com
Epilepsy is a major disorder affecting millions of people. Although modern
electrophysiological and imaging approaches provide high-resolution access to the multi …

[HTML][HTML] Microglia in epilepsy

C Yu, X Deng, D Xu - Neurobiology of Disease, 2023 - Elsevier
Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …