The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …

Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the
Western world and a major health problem, owing to its close association with obesity …

Complement is a critical system of enzymes, regulatory proteins, and receptors that
regulates both innate and adaptive immune responses. Natural mutations in complement …

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the
general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role …

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and it
encompasses a spectrum from simple steatosis to steatohepatitis, fibrosis, or cirrhosis. The …

Background Microglia-mediated neuroinflammation is important in Alzheimer's disease (AD)
pathogenesis. Extracellular deposition of β-amyloid (Aβ), a major pathological hallmark of …

Objective—Reduced plasma adiponectin (APN) in diabetic patients is associated with
endothelial dysfunction. However, APN knockout animals manifest modest systemic …

Adiponectin has well-established insulin-sensitizing effects in non-pregnant individuals.
Pregnant women who are obese or have gestational diabetes typically have low circulating …