The functional structure of proteins results from marginally stable folded conformations.
Reversible unfolding, irreversible denaturation, and deterioration can be caused by …

The expansion of high-quality, low-cost sequencing has created an enormous opportunity to
understand how genetic variants alter cellular behaviour in disease. The high diversity of …

Highly sensitive DNA sequencing techniques have allowed the discovery of large numbers
of somatic mutations in normal tissues. Some mutations confer a competitive advantage over …

Cancer-causing missense mutations in the 3418 amino acid BRCA2 breast and ovarian
cancer suppressor protein frequently affect a short (∼ 340 residue) segment in its carboxyl …

We present here an approach to protein design that combines (i) scarce functional
information such as experimental data (ii) evolutionary information learned from a natural …

The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major
cause for concern for the efficacy of vaccines and control of the pandemic. We show that …

Soybean phytophthora blight is a severe menace to global agriculture, causing annual
losses surpassing USD 1 billion. Present crop loss mitigation strategies primarily rely on …

The overexpression of FGFR1 is thought to significantly contribute to the progression of triple-
negative breast cancer (TNBC), impacting aspects such as tumorigenesis, growth …

Predicting the functionality of missense mutations is extremely difficult. Large-scale genomic
screens are commonly performed to identify mutational correlates or drivers of disease and …

Aims. Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare aggressive
renal malignancy associated with hereditary leiomyomatosis and RCC syndrome (HLRCC) …