Cellular nucleotide pools are often contaminated by base analog nucleotides which interfere
with a plethora of biological reactions, from DNA and RNA synthesis to cellular signaling. An …

Inosine triphosphate pyrophosphatase (ITPase), encoded by the ITPA gene in humans, is an
important enzyme that preserves the integrity of cellular nucleotide pools by hydrolyzing the …

The “mitochondrial Amidoxime Reducing Component”(mARC) is the newly discovered
fourth molybdenum enzyme in mammals. All hitherto analyzed mammals express two mARC …

ABSTRACT A third of humans carry genetic variants of the ITP pyrophosphatase (ITPase)
gene (ITPA) that lead to reduced enzyme activity. Reduced ITPase activity was earlier …

The present study evaluated the impact of variations in the inosine triphosphate
pyrophosphatase (ITPase) gene (ITPA) on treatment outcome in patients with hepatitis C …

Human ITPase (encoded by the ITPA gene) is a protective enzyme which acts to exclude
noncanonical (deoxy) nucleoside triphosphates ((d) NTPs) such as (deoxy) inosine 5 …

Pure nucleotide precursor pools are a prerequisite for high-fidelity DNA replication and the
suppression of mutagenesis and carcinogenesis. ITPases are nucleoside triphosphate …

N-Hydroxylated nucleobases and nucleosides as N-hydroxylaminopurine (HAP) or N-
hydroxyadenosine (HAPR) may be generated endogenously in the course of cell …

Chronic HCV infection comprises a broad spectrum of liver disease, ranging from no or
minimal activity to active hepatitis that in time may progress to severe liver fibrosis, cirrhosis …

Cassava brown streak disease (CBSD) is a leading cause of cassava losses in East and
Central Africa, and is currently having a severe impact on food security. The disease is …