Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …

Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair
pathways are well established to increase lifetime cancer risk. Computational analysis of …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

Purpose Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at
codon 132 have been found in 12% of glioblastomas. Patients and Methods IDH1 codon …

Cancer is a multistage and complex process characterized by molecular alterations that
underlie all three phases of its development:(i) initiation,(ii) promotion and (iii) progression …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …