The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: recommendations from the North American Consortium for Histiocytosis (NACHO)

MB Jordan, CE Allen, J Greenberg… - Pediatric blood & …, 2019 - Wiley Online Library
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

Histiocytic disorders

KL McClain, C Bigenwald, M Collin… - Nature Reviews …, 2021 - nature.com
The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy

G Griffin, S Shenoi, GC Hughes - Best Practice & Research Clinical …, 2020 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Similar but not the same: differential diagnosis of HLH and sepsis

R Machowicz, G Janka, W Wiktor-Jedrzejczak - Critical reviews in oncology …, 2017 - Elsevier
Differential diagnosis of hemophagocytic lymphohistiocytosis (HLH; hemophagocytic
syndrome) and sepsis is critically important because the life-saving aggressive …

Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis

CE Allen, KL McClain - Hematology 2014, the American …, 2015 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme
immune activation, resulting in pathologic inflammation. The diagnosis includes a spectrum …

Epidemiology, characteristics, and outcomes of adult haemophagocytic lymphohistiocytosis in the USA, 2006–19: a national, retrospective cohort study

A Abdelhay, AA Mahmoud, O Al Ali, A Hashem… - …, 2023 - thelancet.com
Background Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening
syndrome characterized by an excessive inflammatory response. Limited data exist on adult …

How to treat involvement of the central nervous system in hemophagocytic lymphohistiocytosis?

AC Horne, R Wickström, MB Jordan, EA Yeh… - … treatment options in …, 2017 - Springer
Opinion statement Central nervous system (CNS)-hemophagocytic lymphohistiocytosis
(HLH) is not a disease in itself, but it is part of a systemic immune response. The vast …

Understanding the spectrum of haemophagocytic lymphohistiocytosis: update on diagnostic challenges and therapeutic options

E Brisse, P Matthys, CH Wouters - British journal of …, 2016 - Wiley Online Library
The cytokine storm syndrome 'haemophagocytic lymphohistiocytosis'(HLH) is an under‐
recognized hyperinflammatory disorder, causing high morbidity and mortality risk in children …

Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis

H Zhang, SW Yang, YC Fu, MC Chen, CH Yang… - Immunologic …, 2022 - Springer
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory
syndrome. The central pathogenesis is an explosive cytokine storm characterized by a …