Haemostatic and vascular biology mechanisms appear to play an important role in the
pathogenesis of placenta‐mediated pregnancy complications. Although low‐dose aspirin …

Adverse pregnancy outcomes, such as pregnancy loss and pre-eclampsia, are associated
with thrombotic mechanisms and thrombophilia. Antithrombotic interventions, particularly …

Introduction: Gestational vascular complications (GVCs), including gestational hypertension
and preeclampsia, are leading causes of maternal morbidity and mortality. Elevated levels of …

Hemochorial placentation is characterized by the development of trophoblast cells
specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell …

Enoxaparin is frequently prescribed for pregnant women who are at high risk for
thromboembolic complications. We conducted a population pharmacokinetics study with 75 …

Obstetrical complications including preeclampsia, fetal growth restriction, preterm labor,
preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of …

Objective. Tissue factor (TF), the major activator of the extrinsic pathway of coagulation, is
abundant in the placenta and decidua. The aim of this study was to determine the maternal …

Pregnancy is a physiological hypercoagulable state, preparing the mother for the hemostatic
challenge of delivery. However, this is associated with an increased risk of venous …

Objective. Preterm labor (PTL) has been associated with an increased thrombin generation
in the maternal circulation and amniotic fluid. Tissue factor (TF) is a potent initiator of the …

Women who have thrombophilia may have an increased risk for placental vascular
complications, including pregnancy loss, pre-eclampsia, intrauterine growth restriction, and …