Influenza is an acute viral respiratory infection that affects all age groups and is associated
with high mortality during pandemics, epidemics, and sporadic outbreaks. Nearly 10% of the …

The SARS-CoV-2 pandemic has seen a notable global reduction in influenza cases of both
influenza A and B viruses. In particular, the B/Yamagata lineage has not been isolated from …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus
infectivity and spread. We previously demonstrated in vitro that the transmembrane protease …

Influenza viruses remain a severe burden to human health because of their contribution to
overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide …

Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy
to combat seasonal influenza infections. IIV activates B cells and T follicular helper (TFH) …

Next-generation vaccines that utilize T cells could potentially overcome the limitations of
current influenza vaccines that rely on antibodies to provide narrow subtype-specific …

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface
expression, is used by many viruses to evade immune recognition. In particular …

Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for
yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs …