The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …

Neuropsychiatric conditions including depression, anxiety disorders, and cognitive
impairment are prevalent in patients with chronic kidney disease (CKD). These conditions …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Rhein is an anthraquinone compound isolated from the medicinal plant rhubarb and mainly
used in the clinical treatment of diabetic nephropathy. Rhein exhibits various renoprotective …

Background: Cognitive impairment, increasingly recognized as a major social burden, is
commonly found in chronic kidney disease (CKD) patients. Summary: Vascular damage …

Abstract αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast
Growth Factor-23, was initially thought to be expressed only in a limited number of tissues …

Ginseng is known to possess anti-aging potential. Klotho mutant mice exhibit phenotypes
that resemble the phenotype of the human aging process. Similar to Klotho deficient mice …

Aging is a multifactorial process associated with an increased susceptibility to
neurodegenerative disorders which can be related to chronic inflammation. Chronic …

In this chapter, we will describe what has been learned about Klotho and its potential
functions in the brain. Klotho is localized in the choroid plexus and, to a lesser extent, in …

Abstract α-Klotho is well described as an anti-aging protein, with critical roles in kidney
function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum. α …