During centriole duplication, a preprocentriole forms at a single site on the mother centriole
through a process that includes the hierarchical recruitment of a conserved set of proteins …

Free‐standing single‐layer β‐sheets are extremely rare in naturally occurring proteins, even
though β‐sheet motifs are ubiquitous. Here we report the crystal structures of three …

Centrioles are microtubule-based organelles that organize the microtubule network and
seed the formation of cilia and flagella. New centrioles assemble through a stepwise …

Centrosomal P4. 1-associated protein (CPAP) is a cell cycle regulated protein fundamental
for centrosome assembly and centriole elongation. In humans, the region between residues …

Peptides and proteins self‐assemble into β‐sheet‐rich fibrils, amyloid, which extends its
structure by incorporating peptide/protein molecules from solution. At the elongation edge …

Centrioles are highly conserved microtubule-based structures that play major roles in cell
division and cell signalling by nucleating the cilium. Several pathologies are associated with …

CPAP is a centriolar protein and its C-terminal domain, G-box or TCP, has a very unique
structure that comprises a single-layer β-sheet without hydrophobic core packing. Here we …

Centrioles are microtubule-based organelles that organize the microtubule network and
seed the formation of cilia and flagella. New centrioles assemble through a stepwise …

Chromosomal Instability (CIN) occurs in over 90% of all sporadic tumors and manifests as
whole chromosome loss or gain, gene deletions, amplifications, inversion, and …