[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity
Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have
been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated …
been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated …
A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
All about the RNA: interferon-stimulated genes that interfere with viral RNA processes
E Yang, MMH Li - Frontiers in immunology, 2020 - frontiersin.org
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to …
disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to …
TRIM proteins and their roles in antiviral host defenses
Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …
The SARS-CoV-2 RNA Interactome
SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to
repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the …
repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the …
Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the …
Z Xu, S Chen, R Liu, H Chen, B Xu, W Xu, M Chen - Molecular Cancer, 2022 - Springer
Background Increasing evidence has demonstrated that circular RNAs (circRNAs) are
implicated in cancer progression. However, the aberrant expression and biological functions …
implicated in cancer progression. However, the aberrant expression and biological functions …
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response
H Lin, M Jiang, L Liu, Z Yang, Z Ma, S Liu, Y Ma… - Nature …, 2019 - nature.com
The helicase RIG-I initiates an antiviral immune response after recognition of pathogenic
RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is …
RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is …