Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

The members of the chromogranin–secretogranin family of peptide hormones, biogenic
amines, and neurotransmitters are enclosed within vesicles in the neuroendocrine system …

Nutritional Biochemistry takes a scientific approach to nutrition. It covers not just" whats"--
nutritional requirements--but why they are required for human health, by describing their …

Human obesity has an inherited component, but in contrast to rodent obesity, precise
genetic defects have yet to be defined1. A mutation of carboxypeptidase E (CPE), an …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

Implantation in humans is a complex process that is temporally and spatially restricted. Over
the past decade, using a one-by-one approach, several genes and gene products that may …

Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

The major endoproteolytic processing enzymes of the secretory pathway are the subtilisin-
like proprotein convertases (SPCs). Furin (SPC1) has emerged as one of the major …

The precursor protein, proopiomelanocortin (POMC), produces many biologically active
peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte …

Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide
hormones within its structure. These peptide hormones can be generated by cleavage of …