Insulin-like growth factor (IGF)-1 is an important neurotrophic hormone. Deficiency of this
hormone has been reported to influence the genesis of cognitive impairment and dementia …

Background The necessity of including both males and females in molecular neuroscience
research is now well understood. However, there is relatively limited basic biological data on …

The prevalence of retinal degenerative diseases, including age-related macular
degeneration and retinitis pigmentosa, has been increasing globally and is linked to the …

Background Age-related cognitive dysfunction, including impairment of hippocampus-
dependent spatial learning and memory, affects approximately half of the aged population …

Background Human studies show that fetal membranes have a limited lifespan and undergo
telomere-dependent cellular senescence that is augmented by oxidative stress and …

Abstract Background Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive
neurodegenerative disease characterized by the degeneration and death of upper (UMN) …

Microglia, the resident immune cells of the central nervous system (CNS), are thought to
contribute to the pathogenesis of age-related neurodegenerative disorders. It has been …

Resident microglia are important to maintain homeostasis in the central nervous system,
which includes the retina. The retinal microglia become activated in numerous pathological …

Purpose To investigate risk factors for the development and progression of diabetic
retinopathy (DR) and long‐term visual outcomes in Dutch patients with type 1 diabetes …

Background Changes to the epigenome with aging, and DNA modifications in particular,
have been proposed as a central regulator of the aging process, a predictor of mortality, and …