Plant secondary metabolites in the battle of drugs and drug-resistant bacteria: new heroes or worse clones of antibiotics?

CL Gorlenko, HY Kiselev, EV Budanova… - Antibiotics, 2020 - mdpi.com
Infectious diseases that are caused by bacteria are an important cause of mortality and
morbidity in all regions of the world. Bacterial drug resistance has grown in the last decades …

Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic …

SB Obakiro, A Kiprop, I Kowino, E Kigondu… - Tropical Medicine and …, 2020 - Springer
Objective Many studies on the treatment of tuberculosis (TB) using herbal medicines have
been undertaken in recent decades in East Africa. The details, however, are highly …

Metabolomic tools used in marine natural product drug discovery

KA Stuart, K Welsh, MC Walker… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: The marine environment is a very promising resource for natural product
research, with many of these reaching the market as new drugs, especially in the field of …

[HTML][HTML] Antimycobacterial and cytotoxic activity of selected medicinal plant extracts

JM Nguta, R Appiah-Opong, AK Nyarko… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Tuberculosis (TB) caused by Mycobacterium tuberculosis
remains an ongoing threat to human health. Several medicinal plants are used traditionally …

Plas-5k: Dataset of protein-ligand affinities from molecular dynamics for machine learning applications

DB Korlepara, CS Vasavi, S Jeurkar, PK Pal, S Roy… - Scientific data, 2022 - nature.com
Computational methods and recently modern machine learning methods have played a key
role in structure-based drug design. Though several benchmarking datasets are available …

Success stories of natural product-based hybrid molecules for multi-factorial diseases

S Choudhary, PK Singh, H Verma, H Singh… - European journal of …, 2018 - Elsevier
Complex diseases comprises of highly complicated etiology resulting in limited applicability
of conventional targeted therapies. Consequently, conventional medicinal compounds suffer …

Therapeutic potential of curcumin as an antimycobacterial agent

N Barua, AK Buragohain - Biomolecules, 2021 - mdpi.com
Curcumin is the principal curcuminoid obtained from the plant Curcuma longa and has been
extensively studied for its biological and chemical properties. Curcumin displays a vast …

Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis

G Arora, A Bothra, G Prosser, K Arora… - The FEBS …, 2021 - Wiley Online Library
Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …

Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors

G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …

[HTML][HTML] Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis

SD Calixto, TLBV Simão, MV Palmeira-Mello… - Bioorganic & Medicinal …, 2022 - Elsevier
Tuberculosis (TB) remains a serious public health problem and one of the main concern is
the emergence of multidrug-resistant and extensively resistant TB. Hyper-reactive patients …