We discuss new approaches to the early detection of keratoconus and recent investigations
regarding the nature of its pathophysiology. We review the current evidence for its complex …

The deposition of amyloid material has been associated with many different diseases.
Although these diseases are very diverse the amyloid material share many common …

Transforming growth factor beta-induced (TGFBI) corneal dystrophies are a group of
inherited progressive corneal diseases. Accumulation of transforming growth factor beta …

Keratoconus (KC) is a corneal disease associated with structural abnormalities in the
corneal epithelium, Bowman's layer and stroma and altered concentration of tear …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Fasciclin I (FAS1) domains have important roles in cell adhesion, which are not understood
despite many structural and functional studies. Examples of FAS1 domain proteins include …

Periostin (PN) and TGF-β-induced protein (βig-h3) are paralogs that contain a single emilin
and four fasciclin-1 modules and are secreted from cells. PN receives attention because of …

Different types of granular corneal dystrophy (GCD) and lattice corneal dystrophy (LCD) are
associated with mutations in the transforming growth factor beta induced gene (TGFBI) …

Hereditary mutations in the transforming growth factor beta induced (TGFBI) gene cause
phenotypically distinct corneal dystrophies characterized by protein deposition in cornea …

A major cause of visual impairment, corneal dystrophies result from accumulation of protein
deposits in the cornea. One of the proteins involved is transforming growth factor β-induced …