Theranostic chimeric antigen receptor (CAR)-T cells: Insight into recent trends and challenges in solid tumors

K Kheyrolahzadeh, MR Tohidkia, A Tarighatnia… - Life Sciences, 2023 - Elsevier
Cell therapy has reached significant milestones in various life-threatening diseases,
including cancer. Cell therapy using fluorescent and radiolabeled chimeric antigen receptor …

Allogeneic chimeric antigen receptor therapy in lymphoma

A Khurana, Y Lin - Current treatment options in oncology, 2022 - Springer
Opinion statement The therapeutic armamentarium has significantly expanded since the
approval of various CD19-targeting chimeric antigen receptor T cell (CAR-T) therapies in …

Genetic and phenotypic attributes of splenic marginal zone lymphoma

F Bonfiglio, A Bruscaggin, F Guidetti… - Blood, The Journal …, 2022 - ashpublications.org
Splenic marginal zone B-cell lymphoma (SMZL) is a heterogeneous clinico-biological entity.
The clinical course is variable, multiple genes are mutated with no unifying mechanism, and …

Fibroblast activation protein and glycolysis in lymphoma diagnosis: comparison of 68Ga-FAPI PET/CT and 18F-FDG PET/CT

X Chen, S Wang, Y Lai, G Wang, M Wei… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Our objective was to compare the diagnostic performance of 68Ga-labeled fibroblast
activation protein (FAP) inhibitor (FAPI) and 18F-labeled FDG PET/CT in diagnosing …

The tumor microenvironment of lymphomas: Insights into the potential role and modes of actions of checkpoint inhibitors

T Menter, A Tzankov, S Dirnhofer - Hematological oncology, 2021 - Wiley Online Library
The tumor microenvironment (TME)–a term comprising non‐neoplastic cells and
extracellular matrix as well as various cytokines, chemokines, growth factors, and other …

Unraveling the role of cancer-associated fibroblasts in B cell lymphoma

P Mukherjee, SM Ansell, P Mondello - Frontiers in immunology, 2024 - frontiersin.org
Recent breakthroughs in research have sparked a paradigm shift in our understanding of
cancer biology, uncovering the critical role of the crosstalk between tumor cells and the …

[HTML][HTML] An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL

LF Prinz, T Riet, DF Neureuther, S Lennartz… - Cell Reports …, 2024 - cell.com
Chimeric antigen receptor T cell (CAR T) therapy is a potent treatment for relapsed/refractory
(r/r) B cell lymphomas but provides lasting remissions in only∼ 40% of patients and is …

Harnessing natural killer cells for refractory/relapsed non-Hodgkin lymphoma: biological roles, clinical trials, and future prospective

M Bakhtiyaridovvombaygi, S Yazdanparast… - Biomarker …, 2024 - Springer
Abstract Non-Hodgkin lymphomas (NHLs) are heterogeneous and are among the most
common hematological malignancies worldwide. Despite the advances in the treatment of …

Immunophenotypic landscape and prognosis-related mRNA signature in diffuse large B cell lymphoma

Y Jiang, H Sun, H Xu, X Hu, W Wu, Y Lv, J Wang… - Frontiers in …, 2022 - frontiersin.org
Diffuse large B cell lymphoma (DLBCL) exhibits a tightly complexity immune landscape. In
this study, we intended to identify different immune phenotype and to examine the immune …

Elevated PTTG1 predicts poor prognosis in kidney renal clear cell carcinoma and correlates with immunity

X Zhang, H Ji, Y Huang, B Zhu, Q Xing - Heliyon, 2023 - cell.com
Background PTTG1 has been reported to be linked with the prognosis and progression of
various cancers, including kidney renal clear cell carcinoma (KIRC). In this article, we mainly …