Autoimmunity against laminin 332

S Patzelt, E Schmidt - Frontiers in Immunology, 2023 - frontiersin.org
Laminin 332 is a heterotrimeric structural protein of the basal membrane zone (BMZ) of the
skin and adjacent mucosal tissues. The importance of laminin 332 for the structural integrity …

Understanding drivers of ocular fibrosis: current and future therapeutic perspectives

F Mallone, R Costi, M Marenco, R Plateroti… - International journal of …, 2021 - mdpi.com
Ocular fibrosis leads to severe visual impairment and blindness worldwide, being a major
area of unmet need in ophthalmology and medicine. To date, the only available treatments …

[HTML][HTML] National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-Host disease: IV. the 2020 highly morbid forms …

D Wolff, V Radojcic, R Lafyatis, R Cinar… - … and cellular therapy, 2021 - Elsevier
Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …

Ocular mucous membrane pemphigoid: current state of pathophysiology, diagnostics and treatment

P Georgoudis, F Sabatino, N Szentmary… - Ophthalmology and …, 2019 - Springer
Mucous membrane pemphigoid (MMP) is a systemic cicatrizing autoimmune disease that
primarily affects orificial mucous membranes, such as the conjunctiva, the nasal cavity, the …

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation

W Jia, JC Poe, H Su, S Anand… - Blood, The Journal …, 2021 - ashpublications.org
Patients with chronic graft-versus-host disease (cGVHD) have increased B cell–activating
factor (BAFF) levels, but whether BAFF promotes disease after allogeneic bone marrow …

Mucous membrane pemphigoid with ocular involvement: the clinical phenotype and its relationship to direct immunofluorescence findings

HS Ong, JF Setterfield, DC Minassian, JK Dart, D Booth… - Ophthalmology, 2018 - Elsevier
Purpose This study explored the validity of the First International Consensus on Mucous
Membrane Pemphigoid (MMP) guidance, which recommends that clinically …

Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice

NJ Reyes, C Yu, R Mathew, CM Kunnen… - Science translational …, 2018 - science.org
Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids
needed to avert tear evaporation and to help maintain ocular surface homeostasis …

Retinoic acid signaling in development and differentiation commitment and its regulatory topology

D Wu, FA Khan, K Zhang, NS Pandupuspitasari… - Chemico-Biological …, 2023 - Elsevier
Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

Visions of eye commensals: the known and the unknown about how the microbiome affects eye disease

AJ St. Leger, RR Caspi - Bioessays, 2018 - Wiley Online Library
Until recently, the ocular surface is thought by many to be sterile and devoid of living
microbes. It is now becoming clear that this may not be the case. Recent and sophisticated …

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

JK Dart - Eye, 2017 - nature.com
This review is in two sections. The first section summarises 35 conditions, both common and
infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given …