Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The amygdala processes and directs inputs and outputs that are key to fear behavior.
However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

Extracellular acid can have important effects on neuron function. In central and peripheral
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …

Acid‐sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis
that are expressed in both central and peripheral nervous systems. Although peripheral …

Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …

While acute inflammation is a natural physiological response to tissue injury or infection,
chronic inflammation is maladaptive and engenders a considerable amount of adverse pain …