Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis
K Kharga, L Kumar, SKS Patel - Biomedicines, 2023 - mdpi.com
Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …
response to an infectious agent and its antigens. Immune cell activation against the antigens …
The protease ADAM17 at the crossroads of disease: Revisiting its significance in inflammation, cancer, and beyond
MI Saad, BJ Jenkins - The FEBS Journal, 2024 - Wiley Online Library
The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the
pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of …
pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of …
ADAM17 activity and IL-6 trans-signaling in inflammation and cancer
N Schumacher, S Rose-John - Cancers, 2019 - mdpi.com
All ligands of the epidermal growth factor receptor (EGF-R) are transmembrane proteins,
which need to be proteolytically cleaved in order to be systemically active. The major …
which need to be proteolytically cleaved in order to be systemically active. The major …
Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes
AW Ku, JB Muhitch, CA Powers, M Diehl, M Kim… - Elife, 2016 - elifesciences.org
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that
drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that …
drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that …
The regulation of neutrophil migration in patients with sepsis: the complexity of the molecular mechanisms and their modulation in sepsis and the heterogeneity of …
Ø Bruserud, KA Mosevoll, Ø Bruserud, H Reikvam… - Cells, 2023 - mdpi.com
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Common causes include gram-negative and gram-positive bacteria as …
response to infection. Common causes include gram-negative and gram-positive bacteria as …
Ectodomain shedding by ADAM17: its role in neutrophil recruitment and the impairment of this process during sepsis
HK Mishra, J Ma, B Walcheck - Frontiers in Cellular and Infection …, 2017 - frontiersin.org
Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and
robust manner during infection. A cascade of adhesion events direct their attachment to the …
robust manner during infection. A cascade of adhesion events direct their attachment to the …
Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells
HK Mishra, N Pore, EF Michelotti… - Cancer Immunology …, 2018 - Springer
Several clinically successful tumor-targeting mAbs induce NK cell effector functions. Human
NK cells exclusively recognize tumor-bound IgG by the FcR CD16A (FcγRIIIA). Unlike other …
NK cells exclusively recognize tumor-bound IgG by the FcR CD16A (FcγRIIIA). Unlike other …
[HTML][HTML] MiR-145 alleviates sepsis-induced inflammatory responses and organ injury by targeting ADAM17
Y Lin, L Liu, Y Lin, R Yang, S Liao, M Xu… - Frontiers in Bioscience …, 2024 - imrpress.com
Background: Current studies have demonstrated that disintegrin and metalloproteinase 17
(ADAM17) plays a critical role in the pathogenesis of sepsis. MicroRNA (miR)-145 is known …
(ADAM17) plays a critical role in the pathogenesis of sepsis. MicroRNA (miR)-145 is known …
Meprin and ADAM proteases as triggers of systemic inflammation in sepsis
S Rahn, C Becker‐Pauly - FEBS letters, 2022 - Wiley Online Library
Systemic inflammatory disorders (SIDs) comprise a broad range of diseases characterized
by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to …
by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to …
[HTML][HTML] EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
N Schumacher, I Thomsen, F Brundert, V Hejret… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract The cytokine interleukin-6 (IL-6) has considerable pro-inflammatory properties and
is a driver of many physiological and pathophysiological processes. Cellular responses to IL …
is a driver of many physiological and pathophysiological processes. Cellular responses to IL …