In this issue of Structure, Holmes et al.(2005) describe elements of an innate defense
mechanism that provides mammals a means to restrict bacterial growth. The host protein …

Obesity may be a low-grade systemic inflammatory disease. Overweight and obese children
and adults have elevated serum levels of C-reactive protein, interleukin-6, tumor necrosis …

Background The cerebral mechanisms underlying the behaviours that lead to pathological
overeating and obesity are poorly understood. Dopamine, a neurotransmitter that modulates …

In the present review, an integrated approach to craving and addiction is discussed, which is
based on recent insights from psychology and neuropsychopharmacology. An integrated …

The number of obese people worldwide has escalated recently, revealing a complex picture
of significant variations among nations and different profiles among adults and children …

Eating represents a choice among many alternative behaviors. The purpose of this review is
to provide an overview of how food reinforcement and behavioral choice theory are related …

Background Hyperglycemia and type 2 diabetes mellitus are more common in
schizophrenia than in the general population. Glucoregulatory abnormalities have also been …

Body weight gain frequently occurs during drug treatment of psychiatric disorders and is
often accompanied by increased appetite or food craving. While occurrence and time course …

Research suggests that the prevalence of obesity in children with autism spectrum disorder
(ASD) is at least as high as that seen in typically developing children. Many of the risk factors …

Objective: Overweight and obesity are common clinical problems encountered in the
treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates …