Genetics, epigenetics and autoimmunity constitute a Bermuda triangle for the pathogenesis of rheumatoid arthritis
S Srivastava, M Rasool - Life Sciences, 2024 - Elsevier
Rheumatoid arthritis (RA), a multigene disorder with a heritability rate of 60%, is
characterized by persistent pain, synovial hyperplasia, and cartilage and bone destruction …
characterized by persistent pain, synovial hyperplasia, and cartilage and bone destruction …
Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases
P Mehta, P Miszta, P Rzodkiewicz, O Michalak… - Life, 2020 - mdpi.com
The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …
Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint …
Abstract Histamine 4 receptor (H4R) is a novel target for the pharmacological modulation of
histamine-mediated immune signals during inflammatory diseases. The purpose of this …
histamine-mediated immune signals during inflammatory diseases. The purpose of this …
CXCR3 antagonist AMG487 suppresses rheumatoid arthritis pathogenesis and progression by shifting the Th17/Treg cell balance
Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by uncontrolled
joint inflammation and damage to bone and cartilage. Previous studies have shown that …
joint inflammation and damage to bone and cartilage. Previous studies have shown that …
Chemokine receptor 5 antagonism causes reduction in joint inflammation in a collagen-induced arthritis mouse model
Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affecting the synovial
joints. A highly potent antagonist of CC chemokine receptor 5 (CCR5), maraviroc (MVC) …
joints. A highly potent antagonist of CC chemokine receptor 5 (CCR5), maraviroc (MVC) …
CXC chemokine receptor 3 antagonist AMG487 shows potent anti-arthritic effects on collagen-induced arthritis by modifying B cell inflammatory profile
Several studies have suggested that chemokine receptors are important mediators of
inflammatory response in rheumatoid arthritis (RA). B cells are also known to play an …
inflammatory response in rheumatoid arthritis (RA). B cells are also known to play an …
[HTML][HTML] Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K/AKT signaling in collagen-induced arthritis
X Cai, Y Zheng, F Ren, S Zhang, L Wu, Y Yao - Biomedicine & …, 2022 - Elsevier
Synovial tissue hyperplasia is a major cause of bone damage in rheumatoid arthritis (RA).
Over-proliferation and secretion of cytokines of fibroblast-like synoviocytes (FLSs) are key …
Over-proliferation and secretion of cytokines of fibroblast-like synoviocytes (FLSs) are key …
Capsanthin from Capsicum annum fruits exerts anti‐glaucoma, antioxidant, anti‐inflammatory activity, and corneal pro‐inflammatory cytokine gene expression in a …
V Shanmugham, R Subban - Journal of Food Biochemistry, 2022 - Wiley Online Library
Dry eye disease (DED) is a complex ocular surface inflammatory disease. Its occurrence
varies widely over the world, ranging from 5% to 34%. The use of preservatives, specifically …
varies widely over the world, ranging from 5% to 34%. The use of preservatives, specifically …
Histamine H4 receptor antagonist ameliorates the progression of experimental autoimmune encephalomyelitis via regulation of T-cell imbalance
Multiple sclerosis (MS) is a degenerative condition characterized by immune-mediated
attacks on the central nervous system (CNS), resulting in demyelination and recurring T-cell …
attacks on the central nervous system (CNS), resulting in demyelination and recurring T-cell …
Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease
X Zhang, X Li, W Ma, F Liu, P Huang, L Wei… - …, 2023 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) has a high fatality rate and
poses a great threat to human health. Astragaloside IV (AS-IV) is proven to attenuate …
poses a great threat to human health. Astragaloside IV (AS-IV) is proven to attenuate …