Abstract The Mexico City Prospective Study is a prospective cohort of more than 150,000
adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in …

The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …

Hispanic/Latino (H/L) populations, although linked by culture and aspects of shared history,
reflect the complexity of history and migration influencing the Americas. The original …

Background Pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) lead to increased risk of
breast, ovarian, and other cancers, but most variant-positive individuals in the general …

Background Elucidation of specific and recurrent/founder pathogenic variants (PVs) in
BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with
high mortality. Most patients present with an advanced stage of the disease, highlighting the …

Background The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in
Tunisia especially in young women and mostly those with family history. However, the …

Cancer is a genomic disease, with driver mutations contributing to tumorigenesis. These
potentially heritable variants influence risk and underlie familial breast cancer (BC). This …

Abstract Background The BRCA1 c. 3331_3334delCAAG founder mutation has been
reported in hereditary breast and ovarian cancer families from multiple Hispanic groups. We …

Abstract The Mexico City Prospective Study (MCPS) is a prospective cohort of over 150,000
adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in …