Update on classical and atypical scrapie in sheep and goats

JJ Greenlee - Veterinary pathology, 2019 - journals.sagepub.com
Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) or prion
disease of sheep and goats. Scrapie is a protein misfolding disease where the normal prion …

Pathogenesis, detection, and control of scrapie in sheep

ED Cassmann, JJ Greenlee - American journal of veterinary …, 2020 - Am Vet Med Assoc
In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a
prion (designated PrP Sc). The normal cellular prion protein (PrP C) is encoded by an …

Second passage of chronic wasting disease of mule deer to sheep by intracranial inoculation compared to classical scrapie

ED Cassmann, RD Frese… - Journal of Veterinary …, 2021 - journals.sagepub.com
The origin of chronic wasting disease (CWD) in cervids is unclear. One hypothesis suggests
that CWD originated from scrapie in sheep. We compared the disease phenotype of sheep …

Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer

RD Kokemuller, SJ Moore, J Bian… - PLoS …, 2023 - journals.plos.org
Prion agents occur in strains that are encoded by the structure of the misfolded prion protein
(PrPSc). Prion strains can influence disease phenotype and the potential for interspecies …

The first report of prion-related protein gene ( PRNT ) polymorphisms in goat

YC Kim, BH Jeong - Acta Veterinaria Hungarica, 2017 - akjournals.com
Prion protein is encoded by the prion protein gene (PRNP). Polymorphisms of several
members of the prion gene family have shown association with prion diseases in several …

Transmission of the atypical/Nor98 scrapie agent to Suffolk sheep with VRQ/ARQ, ARQ/ARQ, and ARQ/ARR genotypes

ED Cassmann, N Mammadova, SJ Moore… - PLoS …, 2021 - journals.plos.org
Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98
scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur …

Sheep with the homozygous lysine-171 prion protein genotype are resistant to classical scrapie after experimental oronasal inoculation

ED Cassmann, SJ Moore, JD Smith… - Veterinary …, 2019 - journals.sagepub.com
Scrapie is a fatal neurodegenerative disease of sheep resulting from the accumulation of a
misfolded form of the prion protein (PrPSc). Polymorphisms in the host prion protein gene …

Sheep are susceptible to the bovine adapted transmissible mink encephalopathy agent by intracranial inoculation and have evidence of infectivity in lymphoid tissues

ED Cassmann, SJ Moore, JD Smith… - Frontiers in Veterinary …, 2019 - frontiersin.org
Transmissible mink encephalopathy (TME) is a food borne prion disease. Epidemiological
and experimental evidence suggests similarities between the agents of TME and L-BSE …

Autoclave treatment of the classical scrapie agent US No. 13-7 and experimental inoculation to susceptible VRQ/ARQ sheep via the oral route results in decreased …

ED Cassmann, N Mammadova, JJ Greenlee - Plos one, 2020 - journals.plos.org
Scrapie, a prion disease of sheep, is highly resistant to conventional deactivation. Numerous
methods to deactivate scrapie have been tested in laboratory animal models, and adequate …

Пріонні хвороби тварин і людини

ЛЄ Корнієнко, ОМ Чечет, ОВ Ложкіна… - 2022 - rep.btsau.edu.ua
У науковій монографії викладено сучасні погляди на пріони та пріонні хвороби тварин і
людини. Автори, ґрунтуючись на наукових працях і сучасних розробках щодо …