Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Traumatic brain injury (TBI) causes persistent cognitive impairment and neurodegeneration.
Environmental enrichment (EE) refers to a housing condition that promotes sensory and …

Background: A new series of malonic acid-based hydrazide derivatives (BPMPDH,
2HPMPDH, 3HPMPDH, 4HPMPDH, DMPDH) were successfully synthesized by the reaction …

Global average life expectancy continues to rise. As aging increases the likelihood of frailty,
which encompasses metabolic, musculoskeletal, and cognitive deficits, there is a need for …

Objectives: The authors sought to identify causal factors that explain the selective benefit of
prehospital administration of thawed plasma (TP) in traumatic brain injury (TBI) patients …

Selective liver X receptor (LXR) agonists have been extensively pursued as therapeutics for
Alzheimer's disease and related dementia (ADRD) and, for comorbidities such as type 2 …

Aged patients often suffer poorer neurological recovery than younger patients after traumatic
brain injury (TBI), but the mechanisms underlying this difference remain unclear. Here, we …

Mitochondrial aldehyde dehydrogenase-2 (ALDH2) metabolizes acetaldehyde to acetate.
People with ALDH2 deficiency and Aldh2-knockout (KO) mice are more susceptible to …

Endogenous aldehydes are produced via tightly regulated metabolic processes and are
rapidly cleared by aldehyde dehydrogenases. However, dysregulation of these processes …

Background: Dysregulated signaling in neurons and astrocytes participates in
pathophysiological alterations seen in the Alzheimer's disease brain, including increases in …