Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases.
The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

The number of sequenced viral genomes has surged recently, presenting an opportunity to
understand viral diversity and uncover unknown regulatory mechanisms. Here, we …

Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …

Genetic lesions that reduce telomerase activity inhibit stem cell replication and cause a
range of incurable diseases, including dyskeratosis congenita (DC) and pulmonary fibrosis …

Background & Aims Chronic coinfection with HBV and HDV leads to the most aggressive
form of chronic viral hepatitis. Herein, we aimed to elucidate the molecular mechanisms …

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of
hospitalizations and hundreds of deaths within the United States in recent years. There is no …

Background Entecavir and tenofovir–disoproxil–fumarate are first-line nucleos (t) ide
analogs (NA) for treatment of hepatitis B virus (HBV) infections; however, their long-term …

TENT4 enzymes generate 'mixed tails' of diverse nucleotides at 3′ ends of RNAs via
nontemplated nucleotide addition to protect messenger RNAs from deadenylation. Here we …