The mechanical response of a homogeneous isotropic linearly elastic material can be fully
characterized by two physical constants, the Young's modulus and the Poisson's ratio, which …

Constitutive models are important to biomechanics for two key reasons. First, constitutive
modelling is an essential component of characterizing tissues' mechanical properties for …

The brain is our softest and most vulnerable organ, and understanding its physics is a
challenging but significant task. Throughout the past decade, numerous competing models …

Constitutive modeling is the cornerstone of computational and structural mechanics. In a
finite element analysis, the constitutive model is encoded in the material subroutine, a …

The viscoelasticity of the crosslinked semiflexible polymer networks—such as the internal
cytoskeleton and the extracellular matrix—that provide shape and mechanical resistance …

The rheology of ultrasoft materials like the human brain is highly sensitive to regional and
temporal variations and to the type of loading. While recent experiments have shaped our …

Many classic hyperelastic models fail to predict the stress responses of soft materials in
complex loading conditions with parameters calibrated through one simple test. To address …

Understanding the constitutive behavior of the human brain is critical to interpret the physical
environment during neurodevelopment, neurosurgery, and neurodegeneration. A wide …

The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a
“glymphatic system” where metabolites are removed from the brain's extracellular space by …

The soft tissue of the brain deforms in response to external stimuli, which can lead to
traumatic brain injury. Constitutive models relate the stress in the brain to its deformation and …