Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

T Jaylet, R Quintens, MA Benotmane… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Brain development during embryogenesis and in early postnatal life is
particularly complex and involves the interplay of many cellular processes and molecular …

Development of a roadmap for action on new approach methodologies in risk assessment

SE Escher, F Partosch, S Konzok… - EFSA Supporting …, 2022 - Wiley Online Library
While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

Establishing a communication and engagement strategy to facilitate the adoption of the adverse outcome pathways in radiation research and regulation

V Chauhan, N Hamada, J Garnier-Laplace… - … journal of radiation …, 2022 - Taylor & Francis
Background Studies on human health and ecological effects of ionizing radiation are rapidly
evolving as innovative technologies arise and the body of scientific knowledge grows …

Increased use of Bayesian network models has improved environmental risk assessments

SJ Moe, JF Carriger, M Glendell - Integrated Environmental …, 2021 - Wiley Online Library
Environmental and ecological risk assessments are defined as the process for evaluating
the likelihood that the environment may be impacted as a result of exposure to stressors …

[HTML][HTML] Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network

N Spînu, MTD Cronin, J Lao, A Bal-Price… - Computational …, 2022 - Elsevier
In a century where toxicology and chemical risk assessment are embracing alternative
methods to animal testing, there is an opportunity to understand the causal factors of …

Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network

S Mentzel, M Grung, R Holten, KE Tollefsen… - Frontiers in …, 2022 - frontiersin.org
The use of Bayesian networks (BN) for environmental risk assessment has increased in
recent years as they offer a more transparent way to characterize risk and evaluate …

Evaluating the effects of climate change and chemical, physical, and biological stressors on nearshore coral reefs: A case study in the Great Barrier Reef, Australia

S Mentzel, R Nathan, P Noyes, KV Brix… - Integrated …, 2024 - Wiley Online Library
An understanding of the combined effects of climate change (CC) and other anthropogenic
stressors, such as chemical exposures, is essential for improving ecological risk …

Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research

V Chauhan, D Beaton, N Hamada… - … Journal of Radiation …, 2022 - Taylor & Francis
Background The purpose of toxicology is to protect human health and the environment. To
support this, the Organisation for Economic Co-operation and Development (OECD) …

Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise

JJ Burtt, J Leblanc, K Randhawa… - … Journal of Radiation …, 2022 - Taylor & Francis
Abstract Purpose The Adverse Outcome Pathway (AOP) framework, a systematic tool that
can link available mechanistic data with phenotypic outcomes of relevance to regulatory …

Incorporating climate projections in the environmental risk assessment of pesticides in aquatic ecosystems

R Oldenkamp, RE Benestad, JD Hader… - Integrated …, 2024 - Wiley Online Library
Global climate change will significantly impact the biodiversity of freshwater ecosystems,
both directly and indirectly via the exacerbation of impacts from other stressors. Pesticides …