Cardiac pathophysiology and the future of cardiac therapies in Duchenne muscular dystrophy

TA Meyers, DW Townsend - International journal of molecular sciences, 2019 - mdpi.com
Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle
wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has …

Dysregulation of calcium handling in duchenne muscular dystrophy-associated dilated cardiomyopathy: mechanisms and experimental therapeutic strategies

ML Law, H Cohen, AA Martin, ABB Angulski… - Journal of clinical …, 2020 - mdpi.com
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease resulting in the loss
of dystrophin, a key cytoskeletal protein in the dystrophin-glycoprotein complex. Dystrophin …

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

EM Houang, YY Sham, FS Bates, JM Metzger - Skeletal muscle, 2018 - Springer
The scientific premise, design, and structure-function analysis of chemical-based muscle
membrane stabilizing block copolymers are reviewed here for applications in striated …

Current pharmacological strategies for Duchenne muscular dystrophy

S Yao, Z Chen, Y Yu, N Zhang, H Jiang… - Frontiers in Cell and …, 2021 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a lethal, X-linked neuromuscular disorder caused
by the absence of dystrophin protein, which is essential for muscle fiber integrity. Loss of …

Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy

N Milad, Z White, AY Tehrani, S Sellers, FMV Rossi… - Skeletal Muscle, 2017 - Springer
Background Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin
expression and leads to severe ambulatory and cardiac function decline. However, the …

Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice

CF Spurney, AD Guerron, Q Yu, A Sali… - BMC cardiovascular …, 2011 - Springer
Abstract Background Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an
increasing cause of death in patients. The absence of dystrophin leads to loss of membrane …

Primary myopathies and the heart

J Finsterer, C Stöllberger - Scandinavian Cardiovascular Journal, 2008 - Taylor & Francis
Myopathies are frequently not confined to the skeletal muscles but also involve other organs
or tissues. One of the most frequently affected organ in addition to the skeletal muscle is the …

Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo

EM Houang, KJ Haman, A Filareto… - … Therapy-Methods & …, 2015 - cell.com
Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration. A
unique therapeutic approach for DMD is the use of synthetic membrane stabilizers to protect …

[HTML][HTML] Molecular and Biochemical Therapeutic Strategies for Duchenne Muscular Dystrophy

L Krishna, A Prashant, YH Kumar, S Paneyala… - Neurology …, 2024 - mdpi.com
Significant progress has been achieved in understanding Duchenne muscular dystrophy
(DMD) mechanisms and developing treatments to slow disease progression. This review …

Cardiac muscle membrane stabilization in myocardial reperfusion injury

EM Houang, J Bartos, BJ Hackel, TP Lodge… - JACC: Basic to …, 2019 - jacc.org
The phospholipid bilayer membrane that surrounds each cell in the body represents the first
and last line of defense for preserving overall cell viability. In several forms of cardiac and …