Sensory perception and emotional disorders are disproportionally represented in men and
women and are thus thought to be modulated by different sex hormones in various …

Opioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical
studies have reported strong evidence for sex-related divergence regarding opioid …

Hormone supplementation is one of the common therapies for menopause-related
disorders. Among different tools, the ovariectomy (OVX) rodents are widely accepted as an …

Irritable bowel syndrome is a gastrointestinal disorder of unknown etiology characterized by
widespread, chronic abdominal pain associated with altered bowel movements. Increasing …

Purpose Several observational studies suggest that estrogens could bias pain perception.
To evaluate the influence of estrogenic impregnation on pain expression, a prospective …

Upregulation of soluble tumor necrosis factor (sTNF) cytokine signaling through TNF
receptor 1 (TNFR1) and subsequent neuronal hyperexcitability are observed in both animal …

Mounting evidence indicates that microRNAs (miRNAs) play critical roles in various
pathophysiological conditions and diseases, but the physiological roles of extracellular …

Hyperalgesia is typified by reduced pain thresholds and heightened responses to painful
stimuli, with a notable prevalence in menopausal women, but the underlying mechanisms …

Postpartum depression (PPD) is a severe mental disorder that affects approximately 10–––
20% of women after childbirth. The precise mechanism underlying PPD pathogenesis …

Abstract Background The Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional
Chinese Medicines (TCM) in the treatment of delayed diabetic wounds. Previous research …