Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS)

A Garg, B Patel, A Abbara, WS Dhillo - Clinical endocrinology, 2022 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and is the leading cause of anovulatory subfertility. Increased …

Sex-biased TGFβ signalling in pulmonary arterial hypertension

M Wits, C Becher, F de Man… - Cardiovascular …, 2023 - academic.oup.com
Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to
pulmonary hypertension and, often fatal, right heart failure. Sex differences in PAH are …

[HTML][HTML] Polycystic ovary syndrome: pathophysiology and therapeutic opportunities

J Dong, DA Rees - BMJ medicine, 2023 - ncbi.nlm.nih.gov
Polycystic ovary syndrome is characterised by excessive levels of androgens and ovulatory
dysfunction, and is a common endocrine disorder in women of reproductive age. Polycystic …

Molecular mechanisms of AMH signaling

JA Howard, KN Hart, TB Thompson - Frontiers in Endocrinology, 2022 - frontiersin.org
Anti-Müllerian Hormone (AMH) is a secreted glycoprotein hormone with critical roles in
reproductive development and regulation. Its chemical and mechanistic similarities to …

An ancient truncated duplication of the anti‐Müllerian hormone receptor type 2 gene is a potential conserved master sex determinant in the Pangasiidae catfish family

M Wen, Q Pan, E Jouanno, J Montfort… - Molecular ecology …, 2022 - Wiley Online Library
The evolution of sex determination (SD) in teleosts is amazingly dynamic, as reflected by the
variety of different master sex‐determining genes identified. Pangasiids are economically …

Genetics of anti-Müllerian hormone and its signaling pathway

N Josso, JY Picard - Best Practice & Research Clinical Endocrinology & …, 2022 - Elsevier
Anti-Müllerian hormone (AMH) is a member of the TGF-β family produced essentially by the
supporting somatic cells of the testis. Initially known for its inhibiting role upon the …

Functional analysis of rare anti-Müllerian hormone protein-altering variants identified in women with PCOS

L Meng, A McLuskey, A Dunaif… - Molecular Human …, 2023 - academic.oup.com
Recently, rare heterozygous AMH protein-altering variants were identified in women with
polycystic ovary syndrome (PCOS), causing reduced anti-Müllerian hormone (AMH) …

Anti-Müllerian hormone signal transduction involved in Müllerian duct regression

RL Cate - Frontiers in Endocrinology, 2022 - frontiersin.org
Over seventy years ago it was proposed that the fetal testis produces a hormone distinct
from testosterone that is required for complete male sexual development. At the time the …

Multi-genome comparisons reveal gain-and-loss evolution of anti-Mullerian hormone receptor type 2 as a candidate master sex-determining gene in Percidae

H Kuhl, PT Euclide, C Klopp, C Cabau, M Zahm… - BMC biology, 2024 - Springer
Abstract Background The Percidae family comprises many fish species of major importance
for aquaculture and fisheries. Based on three new chromosome-scale assemblies in Perca …

A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives

Y Li, L Wei, MC Meinsohn, R Suliman… - Proceedings of the …, 2022 - National Acad Sciences
We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or
MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II …