Regenerative therapies for spinal cord injury

N Ashammakhi, HJ Kim, A Ehsanipour… - … Engineering Part B …, 2019 - liebertpub.com
Spinal cord injury (SCI) is a serious problem that primarily affects younger and middle-aged
adults at its onset. To date, no effective regenerative treatment has been developed. Over …

Current and future therapeutic strategies for Alzheimer's disease: An overview of drug development bottlenecks

Y Peng, H Jin, Y Xue, Q Chen, S Yao, M Du… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common chronic neurodegenerative disease
worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental …

Mitochondrial function in spinal cord injury and regeneration

PG Slater, ME Domínguez-Romero, M Villarreal… - Cellular and Molecular …, 2022 - Springer
Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Targeting the mitochondrial permeability transition pore to prevent age‐associated cell damage and neurodegeneration

AC Kent, KBY El Baradie… - Oxidative medicine and …, 2021 - Wiley Online Library
The aging process is associated with significant alterations in mitochondrial function. These
changes in mitochondrial function are thought to involve increased production of reactive …

Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury

XH Zhou, GD Shi, BY Fan, X Cheng… - International journal …, 2018 - Taylor & Francis
Background Spinal cord injury (SCI) is a traumatic disease of the central nervous system,
accompanied with high incidence and high disability rate. Tissue engineering scaffold can …

Molecular nature and regulation of the mitochondrial permeability transition pore (s), drug target (s) in cardioprotection

M Carraro, A Carrer, A Urbani, P Bernardi - Journal of Molecular and …, 2020 - Elsevier
The mitochondrial permeability transition, an established mechanism for heart diseases, is a
long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection …

Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages-A potential therapeutic approach

M Ahluwalia, M Kumar, P Ahluwalia, S Rahimi… - Neurochemistry …, 2021 - Elsevier
Mitochondria are dynamic organelles responsible for cellular energy production. Besides,
regulating energy homeostasis, mitochondria are responsible for calcium homeostasis …

Mitochondria as a promising target for developing novel agents for treating Alzheimer's disease

EF Shevtsova, AV Maltsev… - Medicinal Research …, 2021 - Wiley Online Library
The mitochondria‐targeting drugs can be conventionally divided into the following groups:
those compensating for the energy deficit involved in neurodegeneration, including …

GDNF gene-engineered adipose-derived stem cells seeded Emu oil-loaded electrospun nanofibers for axonal regeneration following spinal cord injury

K Nejati, D Mehdi, S Ghareghomi, E Mostafavi… - Journal of Drug Delivery …, 2020 - Elsevier
Background Spinal cord injury (SCI) activates a cascade of signaling pathways which results
in impaired sensory and motor function without restoration of function due to the very limited …

Suppression of NLRP3 inflammasome, pyroptosis, and cell death by NIM811 in rotenone-exposed cells as an in vitro model of Parkinson's disease

M Zhang, Q He, G Chen, PA Li - Neurodegenerative Diseases, 2020 - karger.com
Background: Parkinson's disease (PD) is characterized by the selective death of
dopaminergic neurons in the substantia nigra. Recently, NLRP3 inflammasome and …