Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

Background Sepsis and inflammation can cause intensive care unit‐acquired weakness
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …

Background Cancer cachexia is largely irreversible, at least via nutritional means, and
responsible for 20–40% of cancer‐related deaths. Therefore, preventive measures are of …

Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Cachexia occurs in patients with advanced cancers. Despite the adverse clinical impact of
cancer-induced muscle wasting, pathways causing cachexia are controversial, and clinically …

Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …

IL-6 remains a promising therapeutic strategy for attenuating cachexia progression with
many types of cancer. However, improvement of this treatment will require a better …

Skeletal muscle atrophy is a debilitating condition that occurs with aging and disease, but
the underlying mechanisms are incompletely understood. Previous work determined that …