Targeting type I collagen for cancer treatment

R Shi, Z Zhang, A Zhu, X Xiong, J Zhang… - … Journal of Cancer, 2022 - Wiley Online Library
Collagen is the most abundant protein in animals. Interactions between tumor cells and
collagen influence every step of tumor development. Type I collagen is the main fibrillar …

Lipid metabolism reprogramming in cardiac fibrosis

LC Lin, ZY Liu, JJ Yang, JY Zhao, H Tao - Trends in Endocrinology & …, 2024 - cell.com
Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of
cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal …

The role of sphingosine-1-phosphate in autophagy and related disorders

S Xiao, K Peng, C Li, Y Long, Q Yu - Cell Death Discovery, 2023 - nature.com
S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive
properties involved in numerous cellular processes such as cell growth, movement …

[HTML][HTML] Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway

P Sun, Y Wang, Y Ding, J Luo, J Zhong, N Xu, Y Zhang… - Iscience, 2021 - cell.com
Lipotoxicity plays an important role in the development of diabetic heart failure (HF).
Canagliflozin (CAN), a marketed sodium-glucose co-transporter 2 inhibitor, has significantly …

SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation

F Yuan, X Hao, Y Cui, FX Huang, X Zhang, Y Sun… - Cell Death & …, 2022 - nature.com
Germ cell division and differentiation require intimate contact and interaction with the
surrounding somatic cells. Luteinizing hormone (LH) triggers epidermal growth factor (EGF) …

[HTML][HTML] Gaseous signal molecule SO2 regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with …

J Zhao, Q Wu, T Yang, L Nie, S Liu… - The Korean Journal …, 2022 - synapse.koreamed.org
Myocardial fibrosis is a key link in the occurrence and development of diabetic
cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte …

Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis via ERK1/2 signaling pathway

S Luo, Z Yang, R Chen, D You, F Teng, Y Yuan… - Journal of Zhejiang …, 2023 - Springer
Cardiac fibrosis is a cause of morbidity and mortality in people with heart disease. Anti-
fibrosis treatment is a significant therapy for heart disease, but there is still no thorough …

Human umbilical cord-derived stem cell sheets improve left ventricular function in rat models of ischemic heart failure

Y Wu, H Zhang, S Wang, L Li, R Wang… - European Journal of …, 2022 - Elsevier
Introduction Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are among
the most promising cell therapy sources used to treat ischemic heart disease. Cell sheet …

Network Pharmacology‐Based Strategy for Predicting Therapy Targets of Citri Reticulatae Pericarpium on Myocardial Hypertrophy

S Jiang, C Huang, S Wang, B Huang… - BioMed Research …, 2022 - Wiley Online Library
Objective. Through a network pharmacology method, we screened the main active
compounds of Citri Reticulatae Pericarpium (CRP), constructed a drug‐ingredient‐disease …

Attenuated AKT signaling by miR-146a-5p interferes with chicken granulosa cell proliferation, lipid deposition and progesterone biosynthesis

Y Tang, Z Lin, L Liu, L Yin, D Zhang, C Yu, C Yang… - Theriogenology, 2024 - Elsevier
Steroid hormones play a crucial role in the growth and maturation of poultry ovarian follicles,
with progesterone secretion by granulosa cells (GC) being essential. According to our …