Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Background—Delayed afterdepolarizations (DADs) carried by Na+-Ca2+-exchange current
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …

Abstract Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an enzyme with important
regulatory functions in the heart and brain, and its chronic activation can be pathological …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

Many signals have risen and fallen in the tide of investigation into mechanisms of
myocardial hypertrophy and heart failure (HF). In our opinion, the multifunctional Ca and …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Background: CaMKII (Ca2+/calmodulin-dependent kinase II) plays a central role in cardiac
ischemia/reperfusion (I/R) injury—an important therapeutic target for ischemic heart disease …