DNA methylation is an essential epigenetic mark, strongly associated with gene expression
regulation. Aberrant DNA methylation patterns underlie various diseases and efforts to …

As advances in genome engineering inch the technology towards wider clinical use—
slowed by technical and ethical hurdles—a newer offshoot, termed “epigenome …

Fluoromethyl, difluoromethyl, and trifluoromethyl groups are present in numerous
pharmaceuticals and agrochemicals, where they play critical roles in the efficacy and …

Microbial synthetic epigenetics offers significant opportunities for the design of synthetic
biology tools by leveraging reversible gene control mechanisms without altering DNA …

Eosinophils play a crucial role in host defense while also contributing to immunopathology
through the release of inflammatory mediators. Characterized by distinctive cytoplasmic …

We used structure guided mutagenesis and directed enzyme evolution to alter the specificity
of the CG specific bacterial DNA (cytosine-5) methyltransferase M. MpeI. Methylation …

Background Epigenetic variation is mediated by epigenetic marks such as DNA methylation
occurring in all cytosine contexts in plants. CG methylation plays a critical role in silencing …

DNA methylases of the restriction-modifications (RM) systems are promising enzymes for the
development of novel molecular and synthetic biology tools. Their use in vitro enables the …

The advent of locus-specific protein recruitment technologies has enabled a new class of
studies in chromatin biology. Epigenome editors (EEs) enable biochemical modifications of …

Kidolgoztunk egy egyszerű módszert, amellyel a szekvencaspecifikus DNS-fehérje
kölcsönhatás vizsgálható in vivo, Escherichia coliban. Az I-Block-nak nevezett módszer a …