[HTML][HTML] Hydrogen sulfide signaling in mitochondria and disease

B Murphy, R Bhattacharya, P Mukherjee - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

Small-molecule fluorescent probes for H2S detection: Advances and perspectives

H Li, Y Fang, J Yan, X Ren, C Zheng, B Wu… - TrAC Trends in …, 2021 - Elsevier
Since attributed to the involvement in important physiological and pathological processes,
hydrogen sulfide (H 2 S) is regarded as another gasotransmitter like nitric oxide (NO) and …

Hydrogen sulfide in physiology and diseases of the digestive tract

SB Singh, HC Lin - Microorganisms, 2015 - mdpi.com
Hydrogen sulfide (H2S) is a Janus-faced molecule. On one hand, several toxic functions
have been attributed to H2S and exposure to high levels of this gas is extremely hazardous …

A new approach for the prevention and treatment of cardiovascular disorders. Molecular hydrogen significantly reduces the effects of oxidative stress

TW LeBaron, B Kura, B Kalocayova, N Tribulova… - Molecules, 2019 - mdpi.com
Cardiovascular diseases are the most common causes of morbidity and mortality worldwide.
Redox dysregulation and a dyshomeostasis of inflammation arise from, and result in, cellular …

Hydrogen sulfide biology and its role in cancer

S Khattak, MA Rauf, NH Khan, QQ Zhang, HJ Chen… - Molecules, 2022 - mdpi.com
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response

B He, Z Zhang, Z Huang, X Duan, Y Wang, J Cao… - Biochemical …, 2023 - Elsevier
The past few decades have witnessed significant progress in the discovery of hydrogen
sulfide (H 2 S) as a ubiquitous gaseous signaling molecule in mammalian physiology, akin …

Sulfide regulation of cardiovascular function in health and disease

GK Kolluru, RE Shackelford, X Shen… - Nature Reviews …, 2023 - nature.com
Hydrogen sulfide (H2S) has emerged as a gaseous signalling molecule with crucial
implications for cardiovascular health. H2S is involved in many biological functions …

Activatable small-molecule hydrogen sulfide donors

CM Levinn, MM Cerda, MD Pluth - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Hydrogen sulfide (H2S) is an important biological signaling molecule involved
in many physiological processes. These diverse roles have led researchers to develop …

Vascular calcification: New insights into endothelial cells

C Yuan, L Ni, C Zhang, X Hu, X Wu - Microvascular Research, 2021 - Elsevier
Vascular calcification, a common pathological basis of vascular disease, is caused by
various diseases and is an independent risk factor for cardiovascular events. Therefore …

[HTML][HTML] Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury

JL Miljkovic, N Burger, JM Gawel, JF Mulvey… - Redox Biology, 2022 - Elsevier
Mitochondria-targeted H 2 S donors are thought to protect against acute ischemia-
reperfusion (IR) injury by releasing H 2 S that decreases oxidative damage. However, the …