Hypoxia-inducible factor-1α: a promising therapeutic target for vasculopathy in diabetic retinopathy

HY Li, Y Yuan, YH Fu, Y Wang, XY Gao - Pharmacological research, 2020 - Elsevier
Diabetic retinopathy (DR) is a serious condition that can cause blindness in diabetic
patients. It is a neurovascular disease, but the pathogenesis leading to the onset of this …

Protective treatments and their target retinal ganglion cells in diabetic retinopathy

J Zhang, R Liu, HY Kuang, XY Gao, HL Liu - Brain Research Bulletin, 2017 - Elsevier
Diabetic retinopathy (DR) is one of the complications of diabetes which could cause severe
vision loss. Retinal ganglion cell (RGC) injury has been confirmed prior to micro-vascular …

Referral for disease-related visual impairment using retinal photograph-based deep learning: a proof-of-concept, model development study

YC Tham, A Anees, L Zhang, JHL Goh… - The Lancet Digital …, 2021 - thelancet.com
Background In current approaches to vision screening in the community, a simple and
efficient process is needed to identify individuals who should be referred to tertiary eye care …

Association among lipid accumulation product, Chinese visceral obesity index and diabetic retinopathy in patients with type 2 diabetes: a cross-sectional study

X Li, HY Li, ZW Yu, YT Zhang, XW Tong… - … Syndrome and Obesity, 2021 - Taylor & Francis
Background and Aim Obesity often coexists with diabetes, especially abdominal obesity,
recognized as a risk factor for diabetic complications. Diabetic retinopathy (DR), as one of …

The neutrophil percentage‐to‐albumin ratio is related to the occurrence of diabetic retinopathy

X He, F Dai, X Zhang, J Pan - Journal of Clinical Laboratory …, 2022 - Wiley Online Library
Background Among patients with diabetic retinopathy (DR), no proof was available to
confirm the prognostic significance of the neutrophil percentage‐to‐albumin ratio (NPAR) …

Protective potential of klotho protein on diabetic retinopathy: Evidence from clinical and in vitro studies

B Ji, H Wei, Y Ding, H Liang, L Yao… - Journal of Diabetes …, 2020 - Wiley Online Library
Abstract Aims/Introduction The purpose of the present study was to observe the relationship
between serum α‐klotho (KL) protein level and diabetic retinopathy (DR), and to further …

Genetic association of AKR1B1 gene polymorphism rs759853 with diabetic retinopathy risk: A meta-analysis

M Cao, Z Tian, L Zhang, R Liu, Q Guan, J Jiang - Gene, 2018 - Elsevier
Objective The study aimed to ascertain the correlation between AKR1B1 polymorphism
rs759853 and the risk of diabetic retinopathy (DR) through a meta-analysis. Methods Crude …

Global certification of visual impairment registries: A scoping review

LN Cushley, B Leonard‐Hawkhead… - Acta …, 2024 - Wiley Online Library
Background Visual impairment is a global problem which is predicted to rise in the coming
years. Some of the biggest causes of visual impairment globally include uncorrected …

Secretogranin III: a promising therapeutic target for intraocular neovascular lesions

CY Yuan, L Zuo, YC Dong, BX Liu, H Qi - International Ophthalmology, 2025 - Springer
Purpose The purpose of this study is to investigate the role of Secretogranin III (Scg3) in the
pathogenesis of intraocular neovascular diseases and assess its potential as a therapeutic …

Capturing the clinical decision-making processes of expert and novice diabetic retinal graders using a 'think-aloud'approach

K Curran, N Congdon, T Peto, C Dardis, QN Nguyen… - Eye, 2022 - nature.com
Background Diabetic eye screening programmes have been developed worldwide based
on evidence that early detection and treatment of diabetic retinopathy are crucial to …