NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
[HTML][HTML] Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
CA Boecker, J Goldsmith, D Dou, GG Cajka… - Current Biology, 2021 - cell.com
Parkinson's disease-causing mutations in the leucine-rich repeat kinase 2 (LRRK2) gene
hyperactivate LRRK2 kinase activity and cause increased phosphorylation of Rab GTPases …
hyperactivate LRRK2 kinase activity and cause increased phosphorylation of Rab GTPases …
Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets
Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …
whereas axons in the central nervous system are unable to do so. A common and important …
Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
T Uchihara, BI Giasson - Acta neuropathologica, 2016 - Springer
Progressive aggregation of alpha-synuclein (αS) through formation of amorphous pale
bodies to mature Lewy bodies or in neuronal processes as Lewy neurites may be the …
bodies to mature Lewy bodies or in neuronal processes as Lewy neurites may be the …
Modulating NAD+ metabolism, from bench to bedside
E Katsyuba, J Auwerx - The EMBO journal, 2017 - embopress.org
Discovered in the beginning of the 20th century, nicotinamide adenine dinucleotide (NAD+)
has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a …
has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a …
Delayed increases in microvascular pathology after experimental traumatic brain injury are associated with prolonged inflammation, blood–brain barrier disruption …
Traumatic brain injury (TBI) is a significant risk factor for chronic traumatic encephalopathy
(CTE), Alzheimer's disease (AD), and Parkinson's disease (PD). Cerebral microbleeds, focal …
(CTE), Alzheimer's disease (AD), and Parkinson's disease (PD). Cerebral microbleeds, focal …
Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability
DY Yu, SJ Cringle, C Balaratnasingam… - Progress in retinal and …, 2013 - Elsevier
Retinal ganglion cells (RGCs) are specialized projection neurons that relay an immense
amount of visual information from the retina to the brain. RGC signal inputs are collected by …
amount of visual information from the retina to the brain. RGC signal inputs are collected by …
Potential pathways of abnormal tau and α-synuclein dissemination in sporadic Alzheimer's and Parkinson's diseases
H Braak, K Del Tredici - Cold Spring Harbor perspectives …, 2016 - cshperspectives.cshlp.org
Experimental data indicate that transneuronal propagation of abnormal protein aggregates
in neurodegenerative proteinopathies, such as sporadic Alzheimer's disease (AD) and …
in neurodegenerative proteinopathies, such as sporadic Alzheimer's disease (AD) and …