The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer,
and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 …

In multicellular organisms, cell proliferation and death must be regulated to maintain tissue
homeostasis. Many observations suggest that this regulation may be achieved, in part, by …

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall
inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that …

Apoptosis and proliferation are intimately coupled. Some cell cycle regulators can influence
both cell division and programmed cell death. The linkage of cell cycle and apoptosis has …

Fibroblast proliferation and extracellular matrix accumulation characterize idiopathic
pulmonary fibrosis (IPF). We evaluated the presence of tissue inhibitor of metalloproteinase …

The partial cross-utilization of molecules and pathways involved in opposing processes like
cell survival, proliferation and cell death, assures that mutations within one signaling …

Molecular mechanisms of diabetic renal hypertrophy. Altered growth of renal cells is one of
the early abnormalities detected after the onset of diabetes. Cell culture studies whereby …

During the past few years, the focus in plant developmental biology has shifted from
studying the organization of the whole body or individual organs towards the behaviour of …

The transcription factor Forkhead box M1 (FoxM1) is overexpressed in malignant glioma.
However, the functional importance of this factor in human glioma is not known. In the …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …