Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

J Kang, N Brajanovski, KT Chan, J Xuan… - Signal transduction and …, 2021 - nature.com
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

Z Guo, M Ashrafizadeh, W Zhang, R Zou… - Cancer and metastasis …, 2024 - Springer
The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations

AJ De Micheli, JA Spector, O Elemento, BD Cosgrove - Skeletal muscle, 2020 - Springer
Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of
multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq …

Deregulation of ribosomal proteins in human cancers

W El Khoury, Z Nasr - Bioscience Reports, 2021 - portlandpress.com
The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …

Mesenchymal stem cell-derived exosomal microRNA-3940-5p inhibits colorectal cancer metastasis by targeting integrin α6

T Li, Y Wan, Z Su, J Li, M Han, C Zhou - Digestive Diseases and Sciences, 2021 - Springer
Background Exosomes are potential tools for disease control by regulating intercellular
communication through carrying proteins and RNAs between cells or remote organs …

Regulation and functions of α6-integrin (CD49f) in Cancer biology

R Khademi, H Malekzadeh, S Bahrami, N Saki… - Cancers, 2023 - mdpi.com
Simple Summary Integrins play key roles in mediating cell adhesion and delivering chemical
and mechanical signals to the interior of the cell. Consequently, they actively control cellular …

Serum exosomal miRNA-1226 as potential biomarker of pancreatic ductal adenocarcinoma

C Wang, J Wang, W Cui, Y Liu, H Zhou… - OncoTargets and …, 2021 - Taylor & Francis
Background Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of
cancer-related mortality and it is urgent to find biomarkers for early detection of PDAC …

Comprehensive analysis of a nine-gene signature related to tumor microenvironment in lung adenocarcinoma

H Zhong, J Wang, Y Zhu, Y Shen - Frontiers in Cell and …, 2021 - frontiersin.org
Lung adenocarcinoma (LUAD) is the most common malignancy, leading to more than 1
million related deaths each year. Due to low long-term survival rates, the exploration of …

The circ-PITX1 promotes non-small cell lung cancer development via the miR-30e-5p/ITGA6 axis

W Li, P Yang, C Zhong, X Shen, X Shi, X Li - Cell Cycle, 2022 - Taylor & Francis
Non-small cell lung cancer (NSCLC) is one of the most prevalent tumors with high incidence
and mortality across the globe. Recently, increasing studies have demonstrated that circular …

Activation of oncogenic and immune-response pathways is linked to disease-specific survival in Merkel cell carcinoma

B Sundqvist, S Kilpinen, T Böhling, V Koljonen, H Sihto - Cancers, 2022 - mdpi.com
Simple Summary Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer.
Developing targeted therapies for MCC requires increased understanding of the …