Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …

Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that exerts both
homeostatic and pathophysiological roles in the central nervous system. In pathological …

Tumor necrosis factor-α (TNFα) was cloned over 2 decades ago and its identification in part
led to the discovery of a super family of tumor necrosis factors (TNFs) and their receptors …

Microglia are activated in response to a number of different pathological states within the
CNS including injury, ischemia, and infection. Microglial activation results in their production …

The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Background Infliximab is a humanized antibody against tumor necrosis factor α (TNF-α) that
is used in the treatment of Crohn's disease and rheumatoid arthritis. Approximately 147,000 …

CYTOKINES IN ACUTE AND CHRONIC INFLAMMATION Page 1 [Frontiers in Bioscience 2,
d12-26, January 1, 1997] 12 CYTOKINES IN ACUTE AND CHRONIC INFLAMMATION Carol A …

Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1
(TNFRl). We have identified a novel 34 kDa protein, designated TRADD, that specifically …

TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward
normal tissues hampers their application to cancer therapy. Apo2 ligand (Apo2L, or TRAIL) …